Professor Larry Chamley


Research | Current

Major research interests are

  • Extracellular vesicles
  • The causes of trophoblast deportation and its consequences for maternal physiology.
  • Preeclampsia and recurrent miscarriage
  • The life cycle of human placental trophoblasts.
  • The causes of autoimmune reproductive failure with a focus on events surrounding implantation in and infertility in humans and in particular the effects of antiphospholipid antibodies and antisperm antibodies.
  • The biological function of SPRASA, a sperm protein discovered recently by the research team.

Postgraduate supervision

Mancy Tong (PhD Candidate)

Jia Wei  (PhD Candidate)

Teena Gamage  (PhD Candidate)

Megan Alexander  (PhD Candidate)


Director of the BSc/BSc(Hons) programme

Areas of expertise

Reproductive biology

Reproductive Immunology


Selected publications and creative works (Research Outputs)

  • Zhao, M., Li, Y., Xu, L., Hickey, A., Groom, K., Stone, P. R., ... Chen, Q. (2017). Melatonin prevents preeclamptic sera and antiphospholipid antibodies inducing the production of reactive nitrogen species and extrusion of toxic trophoblastic debris from first trimester placentae. Placenta, 58, 17-24. 10.1016/j.placenta.2017.08.001
    Other University of Auckland co-authors: Qi Chen, Tony Hickey, Katie Groom
  • Holland, O. J., Hickey, A. J. R., Alvsaker, A., Moran, S., Hedges, C., Chamley, L. W., & Perkins, A. V. (2017). Changes in mitochondrial respiration in the human placenta over gestation. Placenta, 57, 102-112. 10.1016/j.placenta.2017.06.011
    Other University of Auckland co-authors: Tony Hickey
  • Tong, M., Cheng, S.-B., Chen, Q., DeSousa, J., Stone, P. R., James, J. L., ... Sharma, S. (2017). Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia. Scientific reports, 7 (1)10.1038/s41598-017-07017-x
    Other University of Auckland co-authors: Qi Chen, Jo James
  • Tong, M., Chen, Q., James, J. L., Wise, M. R., Stone, P. R., & Chamley, L. W. (2017). In vivo targets of human placental micro-vesicles vary with exposure time and pregnancy. Reproduction (Cambridge, England), 153 (6), 835-845. 10.1530/rep-16-0615
    Other University of Auckland co-authors: Jo James, Qi Chen
  • James, J. L., Chamley, L. W., & Clark, A. R. (2017). Feeding Your Baby In Utero: How the Uteroplacental Circulation Impacts Pregnancy. Physiology (Bethesda, Md.), 32 (3), 234-245. 10.1152/physiol.00033.2016
    Other University of Auckland co-authors: Alys Clark, Jo James
  • Abrahams, V. M., Chamley, L. W., & Salmon, J. E. (2017). Antiphospholipid Syndrome and Pregnancy: Pathogenesis to Translation. Arthritis & rheumatology (Hoboken, N.J.)10.1002/art.40136
  • Xiao, X., Xiao, F., Zhao, M., Tong, M., Wise, M. R., Stone, P. R., ... Chen, Q. (2017). Treating normal early gestation placentae with preeclamptic sera produces extracellular micro and nano vesicles that activate endothelial cells. Journal of reproductive immunology, 120, 34-41. 10.1016/j.jri.2017.04.004
    Other University of Auckland co-authors: Qi Chen
  • Leon-Martinez, D., Mulla, M. J., Han, C. S., Chamley, L. W., & Abrahams, V. M. (2017). The Impact of Hyperglycemia and Antiphospholipid Syndrome on Trophoblast Function.. Paper presented at 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Orlando, FL. 15 March - 18 March 2017. REPRODUCTIVE SCIENCES. (pp. 1).