Professor Larry Chamley

PhD, FSRB

Research | Current

Major research interests are

  • Extracellular vesicles
  • The causes of trophoblast deportation and its consequences for maternal physiology.
  • Preeclampsia and recurrent miscarriage
  • The life cycle of human placental trophoblasts.
  • The causes of autoimmune reproductive failure with a focus on events surrounding implantation in and infertility in humans and in particular the effects of antiphospholipid antibodies and antisperm antibodies.
  • The biological function of SPRASA, a sperm protein discovered recently by the research team.

Postgraduate supervision

Mancy Tong (PhD Candidate)

Jia Wei  (PhD Candidate)

Teena Gamage  (PhD Candidate)

Megan Alexander  (PhD Candidate)

Responsibilities

Director of the BSc/BSc(Hons) programme

Areas of expertise

Reproductive biology

Reproductive Immunology

 

Selected publications and creative works (Research Outputs)

  • Zhao, M., Li, Y., Xu, L., Hickey, A., Groom, K., Stone, P. R., ... Chen, Q. (2017). Melatonin prevents preeclamptic sera and antiphospholipid antibodies inducing the production of reactive nitrogen species and extrusion of toxic trophoblastic debris from first trimester placentae. Placenta, 58, 17-24. 10.1016/j.placenta.2017.08.001
    Other University of Auckland co-authors: Qi Chen, Tony Hickey, Katie Groom
  • Holland, O. J., Hickey, A. J. R., Alvsaker, A., Moran, S., Hedges, C., Chamley, L. W., & Perkins, A. V. (2017). Changes in mitochondrial respiration in the human placenta over gestation. Placenta, 57, 102-112. 10.1016/j.placenta.2017.06.011
    Other University of Auckland co-authors: Tony Hickey
  • Tong, M., Cheng, S.-B., Chen, Q., DeSousa, J., Stone, P. R., James, J. L., ... Sharma, S. (2017). Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia. Scientific reports, 7 (1)10.1038/s41598-017-07017-x
    Other University of Auckland co-authors: Qi Chen, Jo James
  • Tong, M., Chen, Q., James, J. L., Wise, M. R., Stone, P. R., & Chamley, L. W. (2017). In vivo targets of human placental micro-vesicles vary with exposure time and pregnancy. Reproduction (Cambridge, England), 153 (6), 835-845. 10.1530/rep-16-0615
    Other University of Auckland co-authors: Jo James, Qi Chen
  • James, J. L., Chamley, L. W., & Clark, A. R. (2017). Feeding Your Baby In Utero: How the Uteroplacental Circulation Impacts Pregnancy. Physiology (Bethesda, Md.), 32 (3), 234-245. 10.1152/physiol.00033.2016
    Other University of Auckland co-authors: Alys Clark, Jo James
  • Abrahams, V. M., Chamley, L. W., & Salmon, J. E. (2017). Antiphospholipid Syndrome and Pregnancy: Pathogenesis to Translation. Arthritis & rheumatology (Hoboken, N.J.)10.1002/art.40136
  • Xiao, X., Xiao, F., Zhao, M., Tong, M., Wise, M. R., Stone, P. R., ... Chen, Q. (2017). Treating normal early gestation placentae with preeclamptic sera produces extracellular micro and nano vesicles that activate endothelial cells. Journal of reproductive immunology, 120, 34-41. 10.1016/j.jri.2017.04.004
    Other University of Auckland co-authors: Qi Chen
  • Leon-Martinez, D., Mulla, M. J., Han, C. S., Chamley, L. W., & Abrahams, V. M. (2017). The Impact of Hyperglycemia and Antiphospholipid Syndrome on Trophoblast Function.. Paper presented at 64th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), Orlando, FL. 15 March - 18 March 2017. REPRODUCTIVE SCIENCES. (pp. 1).