Professor Larry Chamley

PhD, FSRB

Research | Current

Major research interests are

  • Extracellular vesicles
  • The causes of trophoblast deportation and its consequences for maternal physiology.
  • Preeclampsia and recurrent miscarriage
  • The life cycle of human placental trophoblasts.
  • The causes of autoimmune reproductive failure with a focus on events surrounding implantation in and infertility in humans and in particular the effects of antiphospholipid antibodies and antisperm antibodies.
  • The biological function of SPRASA, a sperm protein discovered recently by the research team.

Postgraduate supervision

Mancy Tong (PhD Candidate)

Jia Wei  (PhD Candidate)

Teena Gamage  (PhD Candidate)

Megan Alexander  (PhD Candidate)

Responsibilities

Director of the BSc/BSc(Hons) programme

Areas of expertise

Reproductive biology

Reproductive Immunology

 

Selected publications and creative works (Research Outputs)

  • Tong, M., Stanley, J. L., Chen, Q., James, J. L., Stone, P. R., & Chamley, L. W. (2017). Placental nano-vesicles target to specific organs and modulate vascular tone in vivo. Human Reproduction, 32 (11), 2188-2198. 10.1093/humrep/dex310
    Other University of Auckland co-authors: Qi Chen, Jo James
  • Wei, J., Blenkiron, C., Tsai, P., James, J. L., Chen, Q., Stone, P. R., & Chamley, L. W. (2017). Placental trophoblast debris mediated feto-maternal signalling via small RNA delivery: implications for preeclampsia. Scientific reports, 7 (1)10.1038/s41598-017-14180-8
    Other University of Auckland co-authors: Cherie Blenkiron, Peter Tsai, Jo James, Qi Chen
  • Chen, Q., Rutten, V., Cheng, W.-T., Tong, M., Wei, J., Stone, P., ... Chamley, L. W. (2017). Phagocytosis of Extracellular Vesicles Extruded From the Placenta by Ovarian Cancer Cells Inhibits Growth of the Cancer Cells. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society10.1097/igc.0000000000001140
    Other University of Auckland co-authors: Qi Chen, Lai-Ming Ching
  • Zhao, M., Li, Y., Xu, L., Hickey, A., Groom, K., Stone, P. R., ... Chen, Q. (2017). Melatonin prevents preeclamptic sera and antiphospholipid antibodies inducing the production of reactive nitrogen species and extrusion of toxic trophoblastic debris from first trimester placentae. Placenta, 58, 17-24. 10.1016/j.placenta.2017.08.001
    Other University of Auckland co-authors: Qi Chen, Tony Hickey, Katie Groom
  • Chen, Q., Zhao, M., Li, Y., Xu, L., Hickey, A., Groom, K., ... Chamley, L. (2017). Melatonin prevents toxic trophoblastic debris from placentae induced by preeclamptic sera and antiphospholipid antibodies. Placenta. 10.1016/j.placenta.2017.07.173
    Other University of Auckland co-authors: Qi Chen, Katie Groom
  • Gamage, T., Schierding, W., Tsai, P., Ludgate, J., Macaulay, E., Weeks, R., ... James, J. (2017). Global methylation profiling reveals intragenic methylation as a novel regulator of human trophoblast differentiation. Placenta. 10.1016/j.placenta.2017.07.128
    Other University of Auckland co-authors: William Schierding
  • Holland, O. J., Hickey, A. J. R., Alvsaker, A., Moran, S., Hedges, C., Chamley, L. W., & Perkins, A. V. (2017). Changes in mitochondrial respiration in the human placenta over gestation. Placenta, 57, 102-112. 10.1016/j.placenta.2017.06.011
    Other University of Auckland co-authors: Tony Hickey
  • Tong, M., Cheng, S.-B., Chen, Q., DeSousa, J., Stone, P. R., James, J. L., ... Sharma, S. (2017). Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia. Scientific reports, 7 (1)10.1038/s41598-017-07017-x
    Other University of Auckland co-authors: Qi Chen, Jo James