Professor Larry William Chamley

PhD, FSRB

Research | Current

Major research interests are

  • Extracellular vesicles
  • The causes of trophoblast deportation and its consequences for maternal physiology.
  • Preeclampsia and recurrent miscarriage
  • The life cycle of human placental trophoblasts.
  • The causes of autoimmune reproductive failure with a focus on events surrounding implantation in and infertility in humans and in particular the effects of antiphospholipid antibodies and antisperm antibodies.
  • The biological function of SPRASA, a sperm protein discovered recently by the research team.

Postgraduate supervision

Mancy Tong (PhD Candidate)

Jia Wei  (PhD Candidate)

Teena Gamage  (PhD Candidate)

Megan Alexander  (PhD Candidate)

Responsibilities

Director of the BSc/BSc(Hons) programme

Areas of expertise

Reproductive biology

Reproductive Immunology

 

Selected publications and creative works (Research Outputs)

  • Mulla, M. J., Weel, I. C., Potter, J. A., Gysler, S. M., Salmon, J. E., Peraçoli MTS, ... Abrahams, V. M. (2018). Antiphospholipid Antibodies Inhibit Trophoblast Toll-Like Receptor and Inflammasome Negative Regulators. Arthritis & rheumatology (Hoboken, N.J.), 70 (6), 891-902. 10.1002/art.40416
  • Acharya, G., Aplin, J., Brownbill, P., Bulmer, J., Burton, G., Chamley, L., ... Cottrell, E. (2018). IFPA meeting 2017 workshop report: Clinical placentology, 3D structure-based modeling of placental function, placental bed, and treating placental dysfunction. Placenta, 64 Suppl 1, S4-S8. 10.1016/j.placenta.2017.12.011
    Other University of Auckland co-authors: Alys Clark
  • Tong, M., Abrahams, V. M., & Chamley, L. W. (2018). Immunological effects of placental extracellular vesicles. Immunology and cell biology10.1111/imcb.12049
  • Leon-Martinez, D., Mulla, M. J., Han, C. S., Chamley, L. W., & Abrahams, V. M. (2018). Modulation of Trophoblast Function by Combined Hyperglycemia and Antiphospholipid Syndrome is in Part TLR4-Dependent.. Paper presented at 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), San Diego, CA. 6 March - 10 March 2018. REPRODUCTIVE SCIENCES. (pp. 2).
  • Chen, Y., Chen, Q., Xu, L., Groom, K., Hickey, A., & Chamley, L. (2018). Antiphospholipid Antibodies Increase the Activity of Caspases 8 and 9 in the Syncytiotrophoblast of Cultured Placental Explants.. Paper presented at 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), San Diego, CA. 6 March - 10 March 2018. REPRODUCTIVE SCIENCES. (pp. 1).
    Other University of Auckland co-authors: Qi Chen, Katie Groom
  • Pantham, P., & Chamley, L. W. (2018). Harvesting and Characterization of Syncytial Nuclear Aggregates Following Culture of First Trimester Human Placental Explants. (pp. 155-163). 10.1007/978-1-4939-7498-6_12
  • Tong, M., & Chamley, L. W. (2018). Isolation and Characterization of Extracellular Vesicles from Ex Vivo Cultured Human Placental Explants. (pp. 117-129). 10.1007/978-1-4939-7498-6_9
  • Quao, Z. C., Tong, M., Bryce, E., Guller, S., Chamley, L. W., & Abrahams, V. M. (2018). Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies. American journal of reproductive immunology (New York, N.Y. : 1989), 79 (1).10.1111/aji.12785