Professor Larry Chamley


Research | Current

Major research interests are

  • Extracellular vesicles
  • The causes of trophoblast deportation and its consequences for maternal physiology.
  • Preeclampsia and recurrent miscarriage
  • The life cycle of human placental trophoblasts.
  • The causes of autoimmune reproductive failure with a focus on events surrounding implantation in and infertility in humans and in particular the effects of antiphospholipid antibodies and antisperm antibodies.
  • The biological function of SPRASA, a sperm protein discovered recently by the research team.

Postgraduate supervision

Mancy Tong (PhD Candidate)

Jia Wei  (PhD Candidate)

Teena Gamage  (PhD Candidate)

Megan Alexander  (PhD Candidate)


Director of the BSc/BSc(Hons) programme

Areas of expertise

Reproductive biology

Reproductive Immunology


Selected publications and creative works (Research Outputs)

  • Pantham, P., & Chamley, L. W. (2018). Harvesting and characterization of syncytial nuclear aggregates following culture of first trimester human placental explants. Methods in Molecular Biology (pp. 155-163). 10.1007/978-1-4939-7498-6_12
  • Tong, M., & Chamley, L. W. (2018). Isolation and characterization of extracellular vesicles from ex vivo cultured human placental explants. Methods in Molecular Biology (pp. 117-129). 10.1007/978-1-4939-7498-6_9
  • Acharya, G., Aplin, J., Brownbill, P., Bulmer, J., Burton, G., Chamley, L., ... Cottrell, E. (2017). IFPA meeting 2017 workshop report: Clinical placentology, 3D structure-based modeling of placental function, placental bed, and treating placental dysfunction. Placenta10.1016/j.placenta.2017.12.011
    Other University of Auckland co-authors: Alys Clark
  • Quao, Z. C., Tong, M., Bryce, E., Guller, S., Chamley, L. W., & Abrahams, V. M. (2017). Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies. American journal of reproductive immunology (New York, N.Y. : 1989)10.1111/aji.12785
  • Tong, M., Stanley, J. L., Chen, Q., James, J. L., Stone, P. R., & Chamley, L. W. (2017). Placental nano-vesicles target to specific organs and modulate vascular tone in vivo. Human Reproduction, 32 (11), 2188-2198. 10.1093/humrep/dex310
    Other University of Auckland co-authors: Qi Chen, Jo James
  • Wei, J., Blenkiron, C., Tsai, P., James, J. L., Chen, Q., Stone, P. R., & Chamley, L. W. (2017). Placental trophoblast debris mediated feto-maternal signalling via small RNA delivery: implications for preeclampsia. Scientific reports, 7 (1)10.1038/s41598-017-14180-8
    Other University of Auckland co-authors: Cherie Blenkiron, Peter Tsai, Jo James, Qi Chen
  • Chen, Q., Rutten, V., Cheng, W.-T., Tong, M., Wei, J., Stone, P., ... Chamley, L. W. (2017). Phagocytosis of Extracellular Vesicles Extruded From the Placenta by Ovarian Cancer Cells Inhibits Growth of the Cancer Cells. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society10.1097/igc.0000000000001140
    Other University of Auckland co-authors: Qi Chen, Lai-Ming Ching
  • Zhao, M., Li, Y., Xu, L., Hickey, A., Groom, K., Stone, P. R., ... Chen, Q. (2017). Melatonin prevents preeclamptic sera and antiphospholipid antibodies inducing the production of reactive nitrogen species and extrusion of toxic trophoblastic debris from first trimester placentae. Placenta, 58, 17-24. 10.1016/j.placenta.2017.08.001
    Other University of Auckland co-authors: Qi Chen, Tony Hickey, Katie Groom